Interventions to Enhance Testing and Treatment Uptake for Hepatitis C Virus Infection among Healthcare Professions

Abstract

Introduction:

Hepatitis C Virus (HCV) infection represents a significant global health challenge, particularly among healthcare professionals who are at an increased risk of exposure. Despite the availability of effective treatments, the uptake of testing and treatment among this group remains suboptimal. This systematic review aimed to evaluate the effectiveness of interventions designed to enhance testing and treatment uptake for HCV among healthcare professionals, providing evidence-based recommendations to improve HCV management within this key population.

Methods:

The review focused on interventional studies and clinical trials published in the last five years up to 2022. Databases such as PubMed, Scopus, Web of Science, and the Cochrane Library were searched using specific terms related to HCV, healthcare professionals, and intervention strategies. Inclusion criteria were set to consider only interventional studies aimed at increasing HCV testing and/or treatment uptake, while exclusion criteria filtered out non-relevant studies. The selection process involved screening titles and abstracts, followed by full-text reviews to determine eligibility.

Results:

Nine studies were included, revealing a variety of interventions including educational programs, electronic reminder systems, and policy changes. Educational interventions showed moderate increases in testing uptake with risk ratios ranging from 1.2 to 1.5. Electronic reminders significantly impacted testing rates, with a notable study reporting a risk ratio of 2.1 (95% CI, 1.8-2.4). Policy interventions varied in effectiveness but showed potential, with one study achieving a risk ratio of 3.5 (95% CI, 2.7-4.2) for treatment uptake.

Conclusions:

The review indicates that multifaceted interventions are essential for improving HCV testing and treatment uptake among healthcare professionals. Electronic reminders and policy changes, especially those offering free or integrated testing services, appear particularly effective. Implementing tailored strategies that combine educational efforts with practical tools and supportive policies can significantly enhance HCV management in healthcare settings.